Teich Lab
Teich Lab
Basak A, Erol FMB, De Rosa MC, Dong Z, Ogbolu V, Glover HJ, Rausch R, Hargus G, Creus-Muncunill J, Buchanan H, Bai Y, Su Q, Chang B, Adler C, Flaherty D, Ciener B, Xiao H, Reddy H, Aime-Wilson P, Reitz C, Sleeman MW, Altarejos JY, Leibel RL, Qiang LO, Teich AF, Doege CA. Cellular signatures of melanocortin pathway genes across the locus coeruleus. Acta Neuropathol Commun. 2026;14(1):96. doi:10.1186/s40478-026-02287-x
Garcia D, Rai Sharma SR, Saito N, Beckett L, Sevilla LNC, Vasquez R, DeCarli CS, Gutman D, Vizcarra J, Coughlin DG, Teich AF, Garcia L, Mungas DM, Chuah CN, Dugger BN. Clinical and pathologic correlations of machine learning quantification of Aβ deposits across 3 brain regions of decedents with Alzheimer disease. J Neuropathol Exp Neurol. 2026;85(6):537-550. doi:10.1093/jnen/nlaf152
Haq I, Ngo JC, Roy N, Lee E, Choudhury MA, Soni RK, Teich AF, Mayeux RP, De Jager PL, He Y, Wu X, Bennett DA, Olah M, Sher F. Alzheimer's disease risk protein SorLA regulates ER homeostasis and lipid metabolism in human microglia, with conserved effects in neurons. Acta Neuropathol. 2026;151(1):37. doi:10.1007/s00401-026-03002-9
Hobson R, Levy SHS, Singal CMS, Flaherty D, Xiao H, Ciener B, Reddy H, Zabinyakov N, Kim CY, Teich AF, Shneider NA, Bradshaw EM, Elyaman W. Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases. Nat Immunol. 2026;27(2):323-335. doi:10.1038/s41590-025-02401-6
Liang X, Teich AF, Heath LS. Comparative genomics of human brain and immune gene preservation across species. PLoS One. 2026;21(5):e0348713. doi:10.1371/journal.pone.0348713
Patel R, Cheng R, Cardona CL, Angeles E, Singh G, Miller S, Ashok A, Teich AF, Piriz A, Maldonado A, Jimenez-Velazquez IZ, Mayeux R, Lee JH, Sproul AA. Reduced SH3RF3 may protect against Alzheimer's disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling. Glia. 2026;74(7):e70165. doi:10.1002/glia.70165
Richardson TE, Cherry J, Kandoi S, Rohde SK, Uretsky M, Tuz-Zahra F, Bieniek KF, Farrell K, Hefti MM, Miller MB, Tripodis Y, Stein TD, Maldonado-Diaz C, Hiya S, Beach TG, Corrada MM, Dugger BN, Flanagan ME, Frosch MP, Gearing M, Grinberg LT, Hansen LA, Hawes D, Head E, Keene CD, Kofler J, Lee EB, Nelson PT, Oakley DH, Perrin RJ, Rissman RA, Salamat S, Schneider JA, Serrano GE, Teich AF, Troncoso JC, Wisniewski T, Woltjer RL, Crary JF, Dickson DW, McKee AC, Walker JM. Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration. Acta Neuropathol. 2026;151(1):61. doi:10.1007/s00401-026-03031-4
Sloan NX, Mares J, Daly AC, Grier S, Haq I, Jackson CA, Barretto N, Casel O, Kang K, Khiste S, Harris K, Eschbach J, Fullerton BT, Mattison C, Gebremedhin B, Petrescu J, Coie L, Pedersen MH, Zhang K, Shu J, Teich AF, Reddy H, Smith CP, Suh Y, Menon V, Phatnani H. Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex. Cell Genom. 2026;6(2):101127. doi:10.1016/j.xgen.2025.101127
Barbuti PA, Guardia-Laguarta C, Yun T, Chatila ZK, Flowers X, Wong C, Santos BFR, Larsen SB, Lotti JS, Hattori N, Bradshaw E, Dettmer U, Fanning S, Menon V, Reddy H, Teich AF, Krüger R, Area-Gomez E, Przedborski S. The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria-ER membranes. NPJ Parkinsons Dis. 2025;11(1):103. doi:10.1038/s41531-025-00960-x
Cardona CL, Wei L, Kim J, Angeles E, Singh G, Chen S, Patel R, Ifediora N, Canoll P, Teich AF, Hargus G, Chavez A, Sproul AA. High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer's disease. J Neuroinflammation. 2025;22(1):294. doi:10.1186/s12974-025-03562-9
Duy PQ, Kiziltug E, Greenberg ABW, Mehta NH, Hao LT, Fortes C, Mullany S, Fan B, Manichaikul A, Teich AF, Chan D, Alper SL, Hyman BT, Arnold SE, McKhann GM, Frosch MP, Kahle KT. Single-cell elderly blood-CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus. Proc Natl Acad Sci U S A. 2025;122(19):e2412159122. doi:10.1073/pnas.2412159122
Logue MW, Labadorf A, O'Neill NK, Dickson DW, Dugger BN, Flanagan ME, Frosch MP, Gearing M, Jin LW, Kofler J, Mayeux R, McKee A, Miller CA, Murray ME, Nelson PT, Perrin RJ, Schneider JA, Stein TD, Teich AF, Tobunluepop K, Troncoso JC, Wang SH, Wang Z, Wolozin B, Mez J, Farrer LA. Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors. Alzheimers Dement. 2025;21(10):e70629. doi:10.1002/alz.70629
Tian J, Lam TG, Ross SK, Ciener B, Leskinen S, Sivakumar S, Bennett DA, Menon V, McKhann GM, Runnels A, Teich AF. An analysis of RNA quality metrics in human brain tissue. J Neuropathol Exp Neurol. 2025;84(3):236-243. doi:10.1093/jnen/nlae132
Tuddenham JF, Fujita M, Lee E, Nimmagadda N, Khairallah A, Harbison C, Flowers XE, Coronas-Samano G, Maniatis S, Daly A, Schneider JA, Teich AF, Vonsattel JPG, Sims PA, Elyaman W, Bradshaw EM, Ostrow LW, Phatnani H, Shneider NA, Bennett DA, De Jager PL, Przedborski S, Menon V, Olah M. Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord. Acta Neuropathol. 2025;150(1):10. doi:10.1007/s00401-025-02913-3
Bartosch AMW, Youth EHH, Hansen S, Wu Y, Buchanan HM, Kaufman ME, Xiao H, Koo SY, Ashok A, Sivakumar S, Soni RK, Dumitrescu LC, Lam TG, Ropri AS, Lee AJ, Klein HU, Vardarajan BN, Bennett DA, Young-Pearse TL, De Jager PL, Hohman TJ, Sproul AA, Teich AF. ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease. J Neurosci. 2024;44(3):e2324222023. doi:10.1523/JNEUROSCI.2324-22.2023
Bhattarai P, Gunasekaran TI, Belloy ME, Reyes-Dumeyer D, Jülich D, Tayran H, Yilmaz E, Flaherty D, Turgutalp B, Sukumar G, Alba C, McGrath EM, Hupalo DN, Bacikova D, Le Guen Y, Lantigua R, Medrano M, Rivera D, Recio P, Nuriel T, Ertekin-Taner N, Teich AF, Dickson DW, Holley S, Greicius M, Dalgard CL, Zody M, Mayeux R, Kizil C, Vardarajan BN. Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathol. 2024;147(1):70. doi:10.1007/s00401-024-02721-1
Cortese GP, Bartosch AMW, Xiao H, Gribkova Y, Lam TG, Argyrousi EK, Sivakumar S, Cardona C, Teich AF. ZCCHC17 knockdown phenocopies Alzheimer's disease-related loss of synaptic proteins and hyperexcitability. J Neuropathol Exp Neurol. 2024;83(7):626-635. doi:10.1093/jnen/nlae033
Ma Y, Reyes-Dumeyer D, Piriz A, Recio P, Mejia DR, Medrano M, Lantigua RA, Vonsattel JPG, Tosto G, Teich AF, Ciener B, Leskinen S, Sivakumar S, DeTure M, Ranjan D, Dickson D, Murray M, Lee E, Wolk DA, Jin LW, Dugger BN, Hiniker A, Rissman RA, Mayeux R, Vardarajan BN. Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups. Acta Neuropathol. 2024;148(1):27. doi:10.1007/s00401-024-02778-y
Reddy JS, Heath L, Vander Linden A, Allen M, de Paiva Lopes K, Seifar F, Wang E, Ma Y, Poehlman WL, Quicksall ZS, Runnels A, Wang Y, Duong DM, Yin L, Xu K, Modeste ES, Shantaraman A, Dammer EB, Ping L, Oatman SR, Scanlan J, Ho C, Carrasquillo MM, Atik M, Yepez G, Mitchell AO, Nguyen TT, Chen X, Marquez DX, Reddy H, Xiao H, Seshadri S, Mayeux R, Prokop S, Lee EB, Serrano GE, Beach TG, Teich AF, Haroutunian V, Fox EJ, Gearing M, Wingo A, Wingo T, Lah JJ, Levey AI, Dickson DW, Barnes LL, De Jager P, Zhang B, Bennett D, Seyfried NT, Greenwood AK, Ertekin-Taner N. Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations. Alzheimers Dement. 2024;20:7174-7192. doi:10.1002/alz.14208
Ropri AS, Lam TG, Kalia V, Buchanan HM, Bartosch AMW, Youth EHH, Xiao H, Ross SK, Jain A, Chakrabarty JK, Kang MS, Boyett D, Spinazzi EF, Iodice G, McGovern RA, Honig LS, Brown LM, Miller GW, McKhann GM, Teich AF. Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression. Alzheimers Dement. 2024;20(10):7090-7103. doi:10.1002/alz.14194
Roy N, Haq I, Ngo JC, Bennett DA, Teich AF, De Jager PL, Olah M, Sher F. Elevated expression of the retrotransposon LINE-1 drives Alzheimer's disease-associated microglial dysfunction. Acta Neuropathol. 2024;148(1):75. doi:10.1007/s00401-024-02835-6
Tayran H, Yilmaz E, Bhattarai P, Min Y, Wang X, Ma Y, Wang N, Jeong I, Nelson N, Kassara N, Cosacak MI, Dogru RM, Reyes-Dumeyer D, Stenersen JM, Reddy JS, Qiao M, Flaherty D, Gunasekaran TI, Yang Z, Jurisch-Yaksi N, Teich AF, Kanekiyo T, Tosto G, Vardarajan BN, İş Ö, Ertekin-Taner N, Mayeux R, Kizil C. ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling. Cell Genom. 2024;4(9):100642. doi:10.1016/j.xgen.2024.100642
Tuddenham JF, Taga M, Haage V, Marshe VS, Roostaei T, White C, Lee AJ, Fujita M, Khairallah A, Zhang Y, Green G, Hyman B, Frosch M, Hopp S, Beach TG, Serrano GE, Corboy J, Habib N, Klein HU, Soni RK, Teich AF, Hickman RA, Alcalay RN, Shneider N, Schneider J, Sims PA, Bennett DA, Olah M, Menon V, De Jager PL. A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states. Nat Neurosci. 2024;27(12):2521-2537. doi:10.1038/s41593-024-01764-7
Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC, Macpherson HL, Real R, Soto-Beasley AI, Mok K, Revesz T, Christopher EA, DeTure M, Seeley WW, Lee EB, Frosch MP, Molina-Porcel L, Gefen T, Redding-Ochoa J, Ghetti B, Robinson AC, Kobylecki C, Rowe JB, Beach TG, Teich AF, Keith JL, Bodi I, Halliday GM, Gearing M, Arzberger T, Morris CM, White CL 3rd, Mechawar N, Boluda S, MacKenzie IR, McLean C, Cykowski MD, Wang SJ, Graff C, Nagra RM, Kovacs GG, Giaccone G, Neumann M, Ang LC, Carvalho A, Morris HR, Rademakers R, Hardy JA, Dickson DW, Rohrer JD, Ross OA; Pick's disease International Consortium. MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: A genetic association study. Lancet Neurol. 2024;23(5):487-499. doi:10.1016/S1474-4422(24)00083-8
Wang HP, Scalco R, Saito N, Beckett L, Nguyen ML, Huie EZ, Honig LS, DeCarli C, Rissman RA, Teich AF, Mungas DM, Jin LW, Dugger BN. The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease. Acta Neuropathol Commun. 2024;12(1):81. doi:10.1186/s40478-024-01773-4
Bethamcharla R, Reddy H, Teich AF, Sekula RF Jr. Histopathology of the trigeminal ganglion and nerve: A historical review. J Neurosci Res. 2023;101(8):1203-1204. doi:10.1002/jnr.25192
Honig LS, Kang MS, Lee AJ, Reyes-Dumeyer D, Piriz A, Soriano B, Franco Y, Coronado ZD, Recio P, Mejia DR, Medrano M, Lantigua RA, Teich AF, Dage JL, Mayeux R. Evaluation of plasma biomarkers for A/T/N classification of Alzheimer disease among adults of Caribbean Hispanic ethnicity. JAMA Netw Open. 2023;6(4):e238214. doi:10.1001/jamanetworkopen.2023.8214
Huie EZ, Escudero A, Saito N, Harvey D, Nguyen ML, Lucot KL, LaGrande J, Mungas D, DeCarli C, Lamar M, Schneider JA, Kapasi A, Rissman RA, Teich AF, Dugger BN. TDP-43 pathology in the setting of intermediate and high Alzheimer's disease neuropathologic changes: A preliminary evaluation across ethnoracial groups. J Alzheimers Dis. 2023;91(4):1291-1301. doi:10.3233/JAD-220558
Kim YA, Siddiqui T, Blaze J, Cosacak MI, Winters T, Kumar A, Tein E, Sproul AA, Teich AF, Bartolini F, Akbarian S, Kizil C, Hargus G, Santa-Maria I. RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation. Acta Neuropathol. 2023;145(1):29-48. doi:10.1007/s00401-022-02511-7
Nelson PT, Lee EB, Cykowski MD, Alafuzoff I, Arfanakis K, Attems J, Brayne C, Corrada MM, Dugger BN, Flanagan ME, Ghetti B, Grinberg LT, Grossman M, Grothe MJ, Halliday GM, Hasegawa M, Hokkanen SRK, Hunter S, Jellinger K, Kawas CH, Keene CD, Kouri N, Kovacs GG, Leverenz JB, Latimer CS, Mackenzie IR, Mao Q, McAleese KE, Merrick R, Montine TJ, Murray ME, Myllykangas L, Nag S, Neltner JH, Newell KL, Rissman RA, Saito Y, Sajjadi SA, Schwetye KE, Teich AF, Thal DR, Tomé SO, Troncoso JC, Wang SJ, White CL 3rd, Wisniewski T, Yang HS, Schneider JA, Dickson DW, Neumann M. LATE-NC staging in routine neuropathologic diagnosis: An update. Acta Neuropathol. 2023;145(2):159-173. doi:10.1007/s00401-022-02524-2
Scalco R, Saito N, Beckett L, Nguyen ML, Huie E, Wang HP, Flaherty DA, Honig LS, DeCarli C, Rissman RA, Teich AF, Jin LW, Dugger BN. The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer disease. Acta Neuropathol Commun. 2023;11(1):105. doi:10.1186/s40478-023-01574-1
Siddiqui T, Cosacak MI, Popova S, Bhattarai P, Yilmaz E, Lee AJ, Min Y, Wang X, Allen M, İş Ö, Atasavum ZT, Rodriguez-Muela N, Vardarajan BN, Flaherty D, Teich AF, Santa-Maria I, Freudenberg U, Werner C, Tosto G, Mayeux R, Ertekin-Taner N, Kizil C. Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease. NPJ Regen Med. 2023;8(1):33. doi:10.1038/s41536-023-00311-5
Vizcarra JC, Teich AF, Dugger BN, Gutman DA; Alzheimer's Disease Research Center Digital Pathology Working Group. Survey of neuroanatomic sampling and staining procedures in Alzheimer Disease Research Center brain banks. Free Neuropathol. 2023;4. doi:10.17879/freeneuropathology-2023-4696
Beaman C, Kozii K, Hilal S, Liu M, Spagnolo-Allende AJ, Polanco-Serra G, Chen C, Cheng CY, Zambrano D, Arikan B, Del Brutto VJ, Wright C, Flowers XE, Leskinen SP, Rundek T, Mitchell A, Vonsattel JP, Cortes E, Teich AF, Sacco RL, Elkind MSV, Roh D, Gutierrez J; Alzheimer's Disease Neuroimaging Initiative. Cerebral microbleeds, cerebral amyloid angiopathy, and their relationships to quantitative markers of neurodegeneration. Neurology. 2022;98(16):e1605-e1616. doi:10.1212/WNL.0000000000200142
Brickman AM, Manly JJ, Honig LS, Sanchez D, Reyes-Dumeyer D, Lantigua RA, Vonsattel JP, Teich AF, Kang MS, Dage JL, Mayeux R. Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease. Ann Clin Transl Neurol. 2022;9(5):756-761. doi:10.1002/acn3.51529
Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White CL 3rd, Crary JF. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 2022;143(1):33-53. doi:10.1007/s00401-021-02379-z
Brickman AM, Manly JJ, Honig LS, Sanchez D, Reyes-Dumeyer D, Lantigua RA, Lao PJ, Stern Y, Vonsattel JP, Teich AF, Airey DC, Proctor NK, Dage JL, Mayeux R. Plasma p-tau181, p-tau217, and other blood-based Alzheimer's disease biomarkers in a multi-ethnic, community study. Alzheimers Dement. 2021;17(8):1353-1364. doi:10.1002/alz.12301
Huang W, Bartosch AM, Xiao H, Maji S, Youth EHH, Flowers X, Leskinen S, Tomljanovic Z, Iodice G, Boyett D, Spinazzi E, Menon V, McGovern RA, McKhann GM, Teich AF. An immune response characterizes early Alzheimer's disease pathology and subjective cognitive impairment in hydrocephalus biopsies. Nat Commun. 2021;12(1):5659. doi:10.1038/s41467-021-25902-y
Llibre-Guerra JJ, Li Y, Franklin EE, Miller CA, Teich AF, Kofler J, Dickson DW, Ghetti BF, Frosch MP, Halliday GM, McLean C, Lashley T, Gordon BA, Schindler SE, Chen CD, Fagan AM, Benzinger TLS, Wang G, Hassenstab J, Morris JC, Bateman RJ, Perrin RJ, McDade E. Presence of co-pathology in sporadic early-onset Alzheimer disease versus dominantly inherited Alzheimer disease. Alzheimers Dement. 2021;17:e055045. doi:10.1002/alz.055045
Pouliopoulos AN, Kwon N, Jensen G, Meaney A, Niimi Y, Burgess MT, Ji R, McLuckie AJ, Munoz FA, Kamimura HAS, Teich AF, Ferrera VP, Konofagou EE. Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates. Sci Rep. 2021;11(1):15043. doi:10.1038/s41598-021-94188-3
Thakur KT, Miller EH, Glendinning MD, Al-Dalahmah O, Banu MA, Boehme AK, Boubour AL, Bruce SS, Chong AM, Claassen J, Faust PL, Hargus G, Hickman RA, Jambawalikar S, Khandji AG, Kim CY, Klein RS, Lignelli-Dipple A, Lin CC, Liu Y, Miller ML, Moonis G, Nordvig AS, Overdevest JB, Prust ML, Przedborski S, Roth WH, Soung A, Tanji K, Teich AF, Agalliu D, Uhlemann AC, Goldman JE, Canoll P. COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital. Brain. 2021;144(9):2696-2708. doi:10.1093/brain/awab148
Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, Fischer P, Flanagan ME, Franklin E, Gearing M, Glass J, Hansen LA, Haroutunian V, Hof PR, Honig L, Kawas C, Keene CD, Kofler J, Kovacs GG, Lee EB, Lutz MI, Mao Q, Masliah E, McKee AC, McMillan CT, Mesulam MM, Murray M, Nelson PT, Perrin R, Pham T, Poon W, Purohit DP, Rissman RA, Sakai K, Sano M, Schneider JA, Stein TD, Teich AF, Trojanowski JQ, Troncoso JC, Vonsattel JP, Weintraub S, Wolk DA, Woltjer RL, Yamada M, Yu L, White CL, Crary JF. Early selective vulnerability of the CA2 hippocampal subfield in primary age-related tauopathy. J Neuropathol Exp Neurol. 2021;80(2):102-111. doi:10.1093/jnen/nlaa153
Al-Dalahmah O, Thakur KT, Nordvig AS, Prust ML, Roth W, Lignelli A, Uhlemann AC, Miller EH, Kunnath-Velayudhan S, Del Portillo A, Liu Y, Hargus G, Teich AF, Hickman RA, Tanji K, Goldman JE, Faust PL, Canoll P. Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage. Acta Neuropathol Commun. 2020;8(1):147. doi:10.1186/s40478-020-01024-2
Olah M, Menon V, Habib N, Taga MF, Ma Y, Yung CJ, Cimpean M, Khairallah A, Coronas-Samano G, Sankowski R, Grün D, Kroshilina AA, Dionne D, Sarkis RA, Cosgrove GR, Helgager J, Golden JA, Pennell PB, Prinz M, Vonsattel JPG, Teich AF, Schneider JA, Bennett DA, Regev A, Elyaman W, Bradshaw EM, De Jager PL. Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease. Nat Commun. 2020;11(1):6129. doi:10.1038/s41467-020-19737-2
McGovern RA, Nelp TB, Kelly KM, Chan AK, Mazzoni P, Sheth SA, Honig LS, Teich AF, McKhann GM. Predicting cognitive improvement in normal pressure hydrocephalus patients using preoperative neuropsychological testing and cerebrospinal fluid biomarkers. Neurosurgery. 2019;85(4):E662-E669. doi:10.1093/neuros/nyz102
Tariciotti L, Casadei M, Honig LS, Teich AF, McKhann GM 2nd, Tosto G, Mayeux R. Clinical experience with cerebrospinal fluid Aβ42, total and phosphorylated tau in the evaluation of 1,016 individuals for suspected dementia. J Alzheimers Dis. 2018;65(4):1417-1425. doi:10.3233/JAD-180548
Teich AF, Sharma E, Barnwell E, Zhang H, Staniszewski A, Utsuki T, Padmaraju V, Mazell C, Tzekou A, Sambamurti K, Arancio O, Maccecchini ML. Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse. Alzheimers Dement (N Y). 2018;4:37-45. doi:10.1016/j.trci.2017.12.001
Tomljanovic Z, Patel M, Shin W, Califano A, Teich AF. ZCCHC17 is a master regulator of synaptic gene expression in Alzheimer's disease. Bioinformatics. 2018;34(3):367-371. doi:10.1093/bioinformatics/btx608
Xu Z, Lo WS, Beck DB, Schuch LA, Oláhová M, Kopajtich R, Chong YE, Alston CL, Seidl E, Zhai L, Lau CF, Timchak D, LeDuc CA, Borczuk AC, Teich AF, Juusola J, Sofeso C, Müller C, Pierre G, Hilliard T, Turnpenny PD, Wagner M, Kappler M, Brasch F, Bouffard JP, Nangle LA, Yang XL, Zhang M, Taylor RW, Prokisch H, Griese M, Chung WK, Schimmel P. Bi-allelic mutations in Phe-tRNA synthetase associated with a multi-system pulmonary disease support non-translational function. Am J Hum Genet. 2018;103(1):100-114. doi:10.1016/j.ajhg.2018.06.006
Kreisl WC, Lawrence R, Page E, Teich AF, Subramaniam DS, Innis RB, Turner RS. 11C-PBR28 PET detects translocator protein in a patient with astrocytoma and Alzheimer disease. Neurology. 2017;88(10):1001-1004. doi:10.1212/WNL.0000000000003693
Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, Shelanski ML, Checler F, Chami M, Marks AR. Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits. Acta Neuropathol. 2017;134(5):749-767. doi:10.1007/s00401-017-1733-7
Fà M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons MA, Li Puma DD, Chatterjee I, Li J, Saeed F, Berman HL, Ripoli C, Gulisano W, Gonzalez J, Tian H, Costa JA, Lopez P, Davidowitz E, Yu WH, Haroutunian V, Brown LM, Palmeri A, Sigurdsson EM, Duff KE, Teich AF, Honig LS, Sierks M, Moe JG, D'Adamio L, Grassi C, Kanaan NM, Fraser PE, Arancio O. Extracellular tau oligomers produce an immediate impairment of LTP and memory. Sci Rep. 2016;6:19393. doi:10.1038/srep19393
Fà M, Zhang H, Staniszewski A, Saeed F, Shen LW, Schiefer IT, Siklos MI, Tapadar S, Litosh VA, Libien J, Petukhov PA, Teich AF, Thatcher GR, Arancio O. Novel selective calpain 1 inhibitors as potential therapeutics in Alzheimer's disease. J Alzheimers Dis. 2016;49(3):707-721. doi:10.3233/JAD-150618
Koppensteiner P, Trinchese F, Fà M, Puzzo D, Gulisano W, Yan S, Poussin A, Liu S, Orozco I, Dale E, Teich AF, Palmeri A, Ninan I, Boehm S, Arancio O. Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: An early index of Alzheimer's disease. Sci Rep. 2016;6:32553. doi:10.1038/srep32553
Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Mol Neurodegener. 2016;11:35. doi:10.1186/s13024-016-0104-5
Teich AF, Sakurai M, Patel M, Holman C, Saeed F, Fiorito J, Arancio O. PDE5 exists in human neurons and is a viable therapeutic target for neurologic disease. J Alzheimers Dis. 2016;52(1):295-302. doi:10.3233/JAD-151104
Roy SM, Grum-Tokars VL, Schavocky JP, Saeed F, Staniszewski A, Teich AF, Arancio O, Bachstetter AD, Webster SJ, Van Eldik LJ, Minasov G, Anderson WF, Pelletier JC, Watterson DM. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015;6(4):666-680. doi:10.1021/acschemneuro.5b00002
Shaigany S, Dabela E, Teich AF, Husain S, Grossman ME. Resolution of urticarial vasculitis after treatment of neurocysticercosis. J Am Acad Dermatol. 2015;72(1):e32-e33. doi:10.1016/j.jaad.2014.09.017
Gill BJ, Pisapia DJ, Malone HR, Goldstein H, Lei L, Sonabend A, Yun J, Samanamud J, Sims JS, Banu M, Dovas A, Teich AF, Sheth SA, McKhann GM, Sisti MB, Bruce JN, Sims PA, Canoll P. MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma. Proc Natl Acad Sci U S A. 2014;111(34):12550-12555. doi:10.1073/pnas.1405839111
Izzo NJ, Staniszewski A, To L, Fà M, Teich AF, Saeed F, Wostein H, Walko T 3rd, Vaswani A, Wardius M, Syed Z, Ravenscroft J, Mozzoni K, Silky C, Rehak C, Yurko R, Finn P, Look G, Rishton G, Safferstein H, Miller M, Johanson C, Stopa E, Windisch M, Hutter-Paier B, Shamloo M, Arancio O, LeVine H 3rd, Catalano SM. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits. PLoS One. 2014;9(11):e111898. doi:10.1371/journal.pone.0111898
Butler T, Ichise M, Teich AF, Gerard E, Osborne J, French J, Devinsky O, Kuzniecky R, Gilliam F, Pervez F, Provenzano F, Goldsmith S, Vallabhajosula S, Stern E, Silbersweig D. Imaging inflammation in a patient with epilepsy due to focal cortical dysplasia. J Neuroimaging. 2013;23(1):129-131. doi:10.1111/j.1552-6569.2010.00572.x
Teich AF, Patel M, Arancio O. A reliable way to detect endogenous murine β-amyloid. PLoS One. 2013;8(2):e55647. doi:10.1371/journal.pone.0055647
Hashimoto G, Sakurai M, Teich AF, Saeed F, Aziz F, Arancio O. 5-HT4 receptor stimulation leads to soluble AβPPα production through MMP-9 upregulation. J Alzheimers Dis. 2012;32(2):437-445. doi:10.3233/JAD-2012-111235
Qin Z, Luo J, VandeVrede L, Tavassoli E, Fà M, Teich AF, Arancio O, Thatcher GR. Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy. J Med Chem. 2012;55(15):6784-6801. doi:10.1021/jm300353r
Teich AF, Hedley-Whyte ET, Goldman JE. “Pontinization” of the medulla: Two clinical case studies. Neuropathol Appl Neurobiol. 2011;37(6):689-693. doi:10.1111/j.1365-2990.2011.01171.x
Teich AF, Qian N. V1 orientation plasticity is explained by broadly tuned feedforward inputs and intracortical sharpening. Vis Neurosci. 2010;27(1-2):57-73. doi:10.1017/S0952523810000039
Pang ZP, Melicoff E, Padgett D, Liu Y, Teich AF, Dickey BF, Lin W, Adachi R, Südhof TC. Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci. 2006;26(52):13493-13504. doi:10.1523/JNEUROSCI.3519-06.2006
Teich AF, Qian N. Comparison among some models of orientation selectivity. J Neurophysiol. 2006;96(1):404-419. doi:10.1152/jn.00015.2005
Teich AF, Qian N. Learning and adaptation in a recurrent model of V1 orientation selectivity. J Neurophysiol. 2003;89(4):2086-2100. doi:10.1152/jn.00970.2002